Sikeston is located 142 miles south of St. Louis, Missouri and 143 miles north of Memphis, Tennessee in the heart of America. It is strategically located at the intersection of Interstates 55 and 57 along with U.S. Highways 60 and 61. Just 20 miles away lies the confluence of the Mississippi and Ohio rivers. Most major U.S. markets could be accessed in one or two days.